Ovarian & SCLC Initially 1.5 mg/m
2 BSA/day by IV infusion over 30 min daily for 5 consecutive days w/ a 3-wk interval between the start of each course. If dose reduction is chosen for patients who experience severe neutropenia (neutrophil count <0.5 x 10
9/L) ≥7 days, or associated w/ fever or infection, or who have had treatment delayed due to neutropenia, reduced dose by 0.25 mg/m
2/day to 1.25 mg/m
2/day (or subsequently down to 1 mg/m
2/day if necessary).
Cervical carcinoma Initially 0.75 mg/m
2/day as 30-min IV infusion daily on days 1, 2 & 3. Cisplatin is administered as IV infusion on day 1 at a dose of 50 mg/m
2/day following topotecan dose repeated every 21 days for 6 courses. Treatment may continue until disease progression. If dose reduction is chosen for patients who experience severe neutropenia (neutrophil count <0.5 x 10
9/L) ≥7 days, or associated w/ fever or infection, or who have had treatment delayed due to neutropenia, reduced dose by 20% to 0.6 mg/m
2/day for subsequent courses (or subsequently down to 0.45 mg/m
2/day if necessary). In all doses, reduce dose if platelet count falls below 25 x 10
9/L.
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